Journal article
Conditional Survival Probabilities for Patients With Resected Pancreatic Adenocarcinoma
American journal of clinical oncology, v 37(2), pp 107-111
01 Apr 2014
PMID: 23111364
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:
The purpose of this study is to evaluate conditional survival probabilities for patients with resected pancreatic adenocarcinoma (PC).
Methods:
Patients with resected PC from 1998 to 2008 were identified from the Surveillance, Epidemiology and End Results Database. Data on patient, tumor, and treatment characteristics were extracted. Overall survival (OS) rates were calculated using the Kaplan-Meier method. A multivariable analysis at different time points from survival was performed to determine independent prognostic factors associated with all-cause mortality hazard ratios using Cox proportional hazards models.
Results:
A total of 4883 patients with resected PC were identified. The 1-, 3-, and 5-year survival estimates for patients at diagnosis were 67%, 29%, and 21%, respectively. The probability of surviving an additional 1-, 3-, or 5-year conditional upon already surviving 5 years after diagnosis were 89%, 76%, and 71%, respectively. Prognostic factors significantly correlated with improved OS at the time of diagnosis on multivariable analysis include: earlier stage, younger age, later year of diagnosis, white ethnicity, female sex, and residence in a high income district (P < 0.05). Among those already surviving 3 years after diagnosis, younger age was the only prognostic factor statistically significantly correlated with improved OS (P < 0.05).
Conclusions:
Conditional survival estimates provide additional prognostic information that may be used to counsel PC patients on how their prognosis may change over time. Further research using prospectively collected data is warranted to help determine recommended follow-up intervals and benchmarks for future clinical trials.
Metrics
Details
- Title
- Conditional Survival Probabilities for Patients With Resected Pancreatic Adenocarcinoma
- Creators
- Mark V. Mishra - Jefferson College of Health SciencesColin E. Champ - Jefferson CollegeScott W. Keith - Thomas Jefferson UniversityTimothy N. Showalter - Jefferson CollegePramila R. Anne - Jefferson College of Health SciencesYaacov Richard Lawrence - Jefferson College of Health SciencesVoichita Bar-Ad - Thomas Jefferson University
- Publication Details
- American journal of clinical oncology, v 37(2), pp 107-111
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- P30 CA56036 / NCI Cancer Center Support Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30CA056036 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000333713100001
- Scopus ID
- 2-s2.0-84900510698
- Other Identifier
- 991021897374704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology