Journal article
Congenital Anomalies and Resource Utilization in Neonates Infected With Herpes Simplex Virus
Sexually transmitted diseases, v 36(11), pp 680-685
01 Nov 2009
PMID: 19617865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Neonatal herpes simplex virus (HSV) infection, while uncommon, is associated with substantial morbidity and mortality. However, there is little nationally representative data describing resource utilization.
Methods: This retrospective cohort study was conducted using the Pediatric Health Information System, an administrative database that contains discharge diagnosis and resource utilization data from 35 free-standing children's hospitals. Patients <= 60 days of age with a primary discharge diagnosis of HSV were study eligible if they received intravenous acyclovir and were discharged between January 1, 2003 and December 31, 2005.
Results: There were 406 patients with HSV. The median age was 16 days (interquartile range: 8-31 days): 52% of patients were female. Congenital heart disease, the most common congenital anomaly, occurred in 10% of patients. The median length of stay was 15 days; 21 (5%) patients died. HSV was associated with substantial resource utilization. The median hospital charge was $37,431 (interquartile range: $14,667-$74,559) per infant. The presence of congenital heart disease independently increased the hospital length of stay by 93% (adjusted LOS ratio: 1.93; 95% CI: 1.5-2.5).
Conclusions: HSV infection in neonates and young infants was associated with substantial resource utilization. The presence of an underlying congenital cardiac anomaly was associated with a significantly longer length of stay and higher hospital charges.
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Details
- Title
- Congenital Anomalies and Resource Utilization in Neonates Infected With Herpes Simplex Virus
- Creators
- Lilliam Ambroggio - Drexel UniversityScott A. Lorch - Children's Hospital of PhiladelphiaZeinab Mohamad - Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USAJana Mossey - Drexel UniversitySamir S. Shah - Children's Hospital of Philadelphia
- Publication Details
- Sexually transmitted diseases, v 36(11), pp 680-685
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- K01AI073729 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Robert Wood Johnson Foundation; Robert Wood Johnson Foundation (RWJF) K01 AI73729 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000271173900003
- Scopus ID
- 2-s2.0-70350780526
- Other Identifier
- 991019168153304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Infectious Diseases