Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking
American journal of obstetrics and gynecology, v 209(4), pp 332.e1-332.e10
01 Oct 2013
PMID: 23791566
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of the study was to investigate the association between maternal self-reported infections, fever, and smoking in the prenatal period and the subsequent risk for congenital cerebral palsy (CP).
We included the 81,066 mothers of singletons born between 1996 and 2003 who participated in the Danish National Birth Cohort. Children were followed up through December 2008. Information on maternal infections, fever, smoking, and other demographic and lifestyle factors during pregnancy were reported by mothers in computer-assisted telephone interviews in early and midgestation. We identified 139 CP cases including 121 cases of spastic CP (sCP) as confirmed by the Danish National Cerebral Palsy Register. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).
Self-reported vaginal infections were associated with an increased risk of CP and sCP (aHR, 1.52; 95% CI, 1.04–2.24; and aHR, 1.73; 95% CI, 1.16–2.60, respectively) and particularly untreated vaginal infections were associated with an increased risk of sCP (aHR, 1.95; 95% CI, 1.16–3.26). Fever was associated with the risk of CP (aHR, 1.53; 95% CI, 1.06–2.21). Smoking 10 or more cigarettes per day during pregnancy was also associated with sCP (aHR, 1.80; 95% CI, 1.10–2.94). There was a modest excess in risk for children exposed to both heavy smoking and vaginal infections. No other self-reported infections were significantly associated with CP.
Self-reported vaginal infections, fever, and smoking 10 or more cigarettes per day during pregnancy were associated with a higher risk of overall CP and/or sCP.
Metrics
Details
- Title
- Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking
- Creators
- Elani Streja - University of California, Los AngelesJessica E. Miller - University of California, Los AngelesBodil H. Bech - Aarhus University HospitalNaomi Greene - University of California, Los AngelesLars Henning Pedersen - Aarhus University HospitalMarshalyn Yeargin-Allsopp - National Center on Birth Defects and Developmental DisabilitiesKim Van Naarden Braun - National Center on Birth Defects and Developmental DisabilitiesDiana E. Schendel - Centers for Disease Control and PreventionDeborah Christensen - National Center on Birth Defects and Developmental DisabilitiesPeter Uldall - University of Southern DenmarkJørn Olsen - University of California, Los Angeles
- Publication Details
- American journal of obstetrics and gynecology, v 209(4), pp 332.e1-332.e10
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000324698200012
- Scopus ID
- 2-s2.0-84884669884
- Other Identifier
- 991021230005604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology