Journal article
Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population
PloS one, v 6(1), pp e16528-e16528
27 Jan 2011
PMID: 21304590
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.
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Details
- Title
- Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population
- Creators
- Dong V. Wang - Marie CurieJoe Z. Tsien - Augusta University
- Publication Details
- PloS one, v 6(1), pp e16528-e16528
- Publisher
- Public Library of Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000286663900063
- Scopus ID
- 2-s2.0-79551559488
- Other Identifier
- 991020100076504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences