Journal article
Connecting the dots: Epigenetic regulation of extrachromosomal and inherited DNA amplifications
The Journal of biological chemistry, v 301(6), 108454
01 Jun 2025
PMID: 40154613
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
DNA amplification has intrigued scientists for decades. Since its discovery, significant progress has been made in understanding the mechanisms promoting DNA amplification and their associated function(s). While DNA copy gains were once thought to be regulated purely by stochastic processes, recent findings have revealed the important role of epigenetic modifications in driving these amplifications and their integration into the genome. Furthermore, advances in genomic technology have enabled detailed characterization of these genomic events in terms of size, structure, formation, and regulation. This review highlights how our understanding of DNA amplifications has evolved over time, tracing its trajectory from initial discovery to the contemporary landscape. We describe how recent discoveries have started to uncover how these genomic events occur by controlled biological processes rather than stochastic mechanisms, presenting opportunities for therapeutic modulation.
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Details
- Title
- Connecting the dots: Epigenetic regulation of extrachromosomal and inherited DNA amplifications
- Creators
- Chloe Azadegan - Fox Chase Cancer CenterJohn Santoro - Fox Chase Cancer CenterJohnathan R. Whetstine - Fox Chase Cancer Center
- Publication Details
- The Journal of biological chemistry, v 301(6), 108454
- Publisher
- Elsevier
- Grant note
- National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) R35GM144131 / Alfonso Bellacosa and Amy Whitaker P30 CA006927 / University of Arizona Cancer Center (100007345) R35GM144131 / National Institutes of Health (100000002) P30 CA006927 / National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001498943500002
- Scopus ID
- 2-s2.0-105005255921
- Other Identifier
- 991022197330604721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology