Journal article
Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy for the Definitive Treatment of Cervix Cancer
International journal of radiation oncology, biology, physics, v 79(2), pp 348-355
01 Feb 2011
PMID: 20472347
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Accurate target definition is vitally important for definitive treatment of cervix cancer with intensity-modulated radiotherapy (IMRT), yet a definition of clinical target volume (CTV) remains variable within the literature. The aim of this study was to develop a consensus CTV definition in preparation for a Phase 2 clinical trial being planned by the Radiation Therapy Oncology Group.
A guidelines consensus working group meeting was convened in June 2008 for the purposes of developing target definition guidelines for IMRT for the intact cervix. A draft document of recommendations for CTV definition was created and used to aid in contouring a clinical case. The clinical case was then analyzed for consistency and clarity of target delineation using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE), with kappa statistics as a measure of agreement between participants.
Nineteen experts in gynecological radiation oncology generated contours on axial magnetic resonance images of the pelvis. Substantial STAPLE agreement sensitivity and specificity values were seen for gross tumor volume (GTV) delineation (0.84 and 0.96, respectively) with a kappa statistic of 0.68 (
p < 0.0001). Agreement for delineation of cervix, uterus, vagina, and parametria was moderate.
This report provides guidelines for CTV definition in the definitive cervix cancer setting for the purposes of IMRT, building on previously published guidelines for IMRT in the postoperative setting.
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Details
- Title
- Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy for the Definitive Treatment of Cervix Cancer
- Creators
- Karen Lim - Princess Margaret Cancer CentreWilliam Small - Northwestern UniversityLorraine Portelance - McGill University Health CentreCarien Creutzberg - Leiden University Medical CenterIna M. Jürgenliemk-Schulz - University Medical Center UtrechtArno Mundt - University of California, San DiegoLoren K. Mell - University of California, San DiegoNina Mayr - The Ohio State UniversityAkila Viswanathan - Harvard UniversityAnuja Jhingran - The University of Texas MD Anderson Cancer CenterBeth Erickson - Medical College of WisconsinJennifer De Los Santos - University of Alabama at BirminghamDavid Gaffney - Huntsman Cancer InstituteCatheryn Yashar - University of California, San DiegoSushil Beriwal - Magee-Womens HospitalAaron Wolfson - University of MiamiAlexandra Taylor - Hammersmith HospitalWalter Bosch - Washington University in St. LouisIssam El Naqa - Washington University in St. LouisAnthony Fyles - Princess Margaret Cancer CentreGyn IMRT Consortium
- Publication Details
- International journal of radiation oncology, biology, physics, v 79(2), pp 348-355
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000286451000005
- Scopus ID
- 2-s2.0-78650820563
- Other Identifier
- 991021897291004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging