Journal article
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma
International journal of radiation oncology, biology, physics, v 95(4), pp 1191-1200
15 Jul 2016
PMID: 27130794
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to develop a radiation therapy (RT) contouring atlas and recommendations for women with postoperative and locally advanced vulvar carcinoma.
An international committee of 35 expert gynecologic radiation oncologists completed a survey of the treatment of vulvar carcinoma. An initial set of recommendations for contouring was discussed and generated by consensus. Two cases, 1 locally advanced and 1 postoperative, were contoured by 14 physicians. Contours were compared and analyzed using an expectation-maximization algorithm for simultaneous truth and performance level estimation (STAPLE), and a 95% confidence interval contour was developed. The level of agreement among contours was assessed using a kappa statistic. STAPLE contours underwent full committee editing to generate the final atlas consensus contours.
Analysis of the 14 contours showed substantial agreement, with kappa statistics of 0.69 and 0.64 for cases 1 and 2, respectively. There was high specificity for both cases (≥99%) and only moderate sensitivity of 71.3% and 64.9% for cases 1 and 2, respectively. Expert review and discussion generated consensus recommendations for contouring target volumes and treatment for postoperative and locally advanced vulvar cancer.
These consensus recommendations for contouring and treatment of vulvar cancer identified areas of complexity and controversy. Given the lack of clinical research evidence in vulvar cancer radiation therapy, the committee advocates a conservative and consistent approach using standardized recommendations.
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Details
- Title
- Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma
- Creators
- David K Gaffney - Huntsman (United States)Bronwyn King - Peter MacCallum Cancer CentreAkila N Viswanathan - Harvard UniversityMaroie Barkati - Centre Hospitalier de l’Université de MontréalSushil Beriwal - UPMC Hillman Cancer CenterPatricia Eifel - The University of Texas MD Anderson Cancer CenterBeth Erickson - Department of Radiation Oncology, Proedtert and Medical College Clinical Cancer Center, Milwaukee, WisconsinAnthony Fyles - Princess Margaret Cancer CentreJennifer Goulart - BC Cancer AgencyMatthew Harkenrider - Loyola University ChicagoAnuja Jhingran - The University of Texas MD Anderson Cancer CenterAnn Klopp - The University of Texas MD Anderson Cancer CenterWui-Jin Koh - University of WashingtonKaren Lim - Liverpool HospitalIvy Petersen - Mayo ClinicLorraine Portelance - University of MiamiWilliam Small, Jr - Universidad Loyola AndalucíaAlexandra Stewart - Royal Surrey County HospitalEricka Wiebe - Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, CanadaAaron Wolfson - University of MiamiCatheryn Yashar - University of California San DiegoWalter Bosch - Washington University in St. Louis
- Publication Details
- International journal of radiation oncology, biology, physics, v 95(4), pp 1191-1200
- Publisher
- Elsevier
- Grant note
- U10 CA180868 / NCI NIH HHS U24 CA180803 / NCI NIH HHS U10 CA180818 / NCI NIH HHS UG1 CA233178 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000378207000015
- Scopus ID
- 2-s2.0-84964613702
- Other Identifier
- 991021897264704721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging