Journal article
Conserved MHC Class I–Presented Dengue Virus Epitopes Identified by Immunoproteomics Analysis Are Targets for Cross-Serotype Reactive T-Cell Response
The Journal of infectious diseases, v 205(4), pp 647-655
13 Jan 2012
PMID: 22246683
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dengue fever and dengue hemorrhagic fever are significant global public health problems, and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive T-cell responses. Currently, there are no available tools to assess protective T-cell responses during infection or after vaccination. In this study, we utilize an immunoproteomics process to uncover novel HLA-A2–specific epitopes derived from dengue virus (DV)–infected cells. These epitopes are conserved, and we report that epitope-specific cytotoxic lymphocytes (CTLs) are cross-reactive against all 4 DV serotypes. These epitopes have potential as new informational and diagnostic tools to characterize T-cell immunity in DV infection and may serve as part of a universal vaccine candidate complementary to current vaccines in trial.
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Details
- Title
- Conserved MHC Class I–Presented Dengue Virus Epitopes Identified by Immunoproteomics Analysis Are Targets for Cross-Serotype Reactive T-Cell Response
- Creators
- James S. Testa - Immunotope Inc, Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA.Vivekananda Shetty - Immunotope Inc, Pennsylvania Biotechnology Center, DoylestownGomathinayagam Sinnathamby - Immunotope Inc, Pennsylvania Biotechnology Center, DoylestownZacharie Nickens - Immunotope Inc, Pennsylvania Biotechnology Center, DoylestownJulie Hafner - Immunotope Inc, Pennsylvania Biotechnology Center, DoylestownShivali Kamal - Immunotope Inc, Pennsylvania Biotechnology Center, DoylestownXianchao Zhang - Drexel UniversityMarti Jett - Walter Reed Army Institute of ResearchRamila Philip - Immunotope (United States)
- Publication Details
- The Journal of infectious diseases, v 205(4), pp 647-655
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000299795000018
- Scopus ID
- 2-s2.0-84863056134
- Other Identifier
- 991019167874204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology