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Considerations towards the better integration of epidemiology into quantitative risk assessment
Journal article   Open access   Peer reviewed

Considerations towards the better integration of epidemiology into quantitative risk assessment

Sandrine Déglin, Igor Burstyn, Connie Chen, David Miller, Ali Hamade, Ellen Chang, Raghavendhran Avanasi, Denali Boon, Jennifer Reed and Matthew Gribble
Global Epidemiology, v 4, 100084
01 Dec 2022
DOI: https://doi.org/10.1016/j.gloepi.2022.100084
url
https://doi.org/10.1016/j.gloepi.2022.100084View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Environmental epidemiology has proven critical to study various associations between environmental exposures and adverse human health effects. However, there is a perception that it often does not sufficiently inform quantitative risk assessment. To help address this concern, in 2017, the Health and Environmental Sciences Institute initiated a project engaging the epidemiology, exposure science, and risk assessment communities with tripartite representation from government agencies, industry, and academia, in a dialogue on the use of environmental epidemiology for quantitative risk assessment and public health decision making. As part of this project, four meetings attended by experts in epidemiology, exposure science, toxicology, statistics, and risk assessment, as well as one additional meeting engaging funding agencies, were organized to explore incentives and barriers to realizing the full potential of epidemiological data in quantitative risk assessment. A set of questions was shared with workshop participants prior to the meetings, and two case studies were used to support the discussion. Five key ideas emerged from these meetings as areas of desired improvement to ensure that human data can more consistently become an integral part of quantitative risk assessment: 1) reducing confirmation and publication bias, 2) increasing communication with funding agencies to raise awareness of research needs, 3) developing alternative funding channels targeted to support quantitative risk assessment, 4) making data available for reuse and analysis, and 5) developing cross-disciplinary and cross-sectoral interactions, collaborations, and training. We explored and integrated these themes into a roadmap illustrating the need for a multi-stakeholder effort to ensure that epidemiological data can fully contribute to the quantitative evaluation of human health risks, and to build confidence in a reliable decision-making process that leverages the totality of scientific evidence.

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