Journal article
Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex
Neuron (Cambridge, Mass.), v 96(1), pp 228-241
27 Sep 2017
PMID: 28957671
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Structured knowledge is thought to form, in part, through the extraction and representation of regularities across overlapping experiences. However, little is known about how consolidation processes may transform novel episodic memories to reflect such regularities. In a multi-day fMRI study, participants encoded trial-unique associations that shared features with other trials. Multi-variate pattern analyses were used to measure neural similarity across overlapping and non-overlapping memories during immediate and 1-week retrieval of these associations. We found that neural patterns in the hippocampus and medial prefrontal cortex represented the featural overlap across memories, but only after a week. Furthermore, after a week, the strength of a memory’s unique episodic reinstatement during retrieval was inversely related to its representation of overlap, suggesting a trade-off between the integration of related memories and recovery of episodic details. These findings suggest that consolidation-related changes in neural representations support the gradual organization of discrete episodes into structured knowledge.
•Patterns in mPFC and hippocampus represent featural overlap across remote memories•Hippocampal encoding patterns are reinstated during remote retrieval•Reinstatement is inversely related to the representation of overlap in hippocampus•Encoding-related changes in functional connectivity relate to measures of overlap
Using functional MRI in humans, Tompary et al. track time-dependent representational changes across overlapping and non-overlapping episodic memories. The authors demonstrate that neural patterns of memories in mPFC and hippocampus become restructured over time to represent overlap across memories.
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Details
- Title
- Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex
- Creators
- Alexa Tompary - New York UniversityLila Davachi - New York University
- Publication Details
- Neuron (Cambridge, Mass.), v 96(1), pp 228-241
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000411845100022
- Scopus ID
- 2-s2.0-85031015279
- Other Identifier
- 991021463615104721
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