Journal article
Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task
The Journal of neuroscience, v 35(19), pp 7326-7331
13 May 2015
PMID: 25972163
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is well established that the hippocampus and perirhinal cortex (PrC) encode associative and item representations, respectively. However, less is known about how item and associative memories are consolidated. We used high-resolution fMRI in humans to measure how functional connectivity between these distinct medial temporal lobe regions with the ventral tegmental area (VTA) after a paired associate encoding task is related to both immediate and 24 h item and associative memory performance. We found that the strength of post-encoding functional connectivity between the VTA and CA1 selectively correlated with long-term associative memory, despite subjects actively engaging in an unrelated task during this period. Conversely, VTA-PrC functional connectivity during the same period correlated with long-term item memory. Critically, connectivity between VTA and these MTL regions were only related to memory tested at a 24 h delay, implicating midbrain connectivity in the consolidation of distinct forms of memory.
Metrics
Details
- Title
- Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task
- Creators
- Alexa Tompary - Department of Psychology andKatherine Duncan - Columbia UniversityLila Davachi - New York University
- Publication Details
- The Journal of neuroscience, v 35(19), pp 7326-7331
- Publisher
- Society for Neuroscience
- Grant note
- MH074692 / NIMH NIH HHS R01 MH074692 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000356668800003
- Scopus ID
- 2-s2.0-84929353509
- Other Identifier
- 991021448173904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences