Journal article
Constipation: an emerging risk factor for Parkinson's disease?
European journal of neurology, v 23(11), pp 1606-1613
01 Nov 2016
PMID: 27444575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Constipation is the most prominent and disabling manifestation of lower gastrointestinal (GI) dysfunction in Parkinson's disease (PD). The prevalence of constipation in PD patients ranges from 24.6% to 63%; this variability is due to the different criteria used to define constipation and to the type of population enrolled in the studies. In addition, constipation may play an active role in the pathophysiological changes that underlie motor fluctuations in advanced PD through its negative effects on absorption of levodopa. Several clinical studies now consistently suggest that constipation may precede the first occurrence of classical motor features in PD. Studies in vivo, using biopsies of the GI tract and more recently functional imaging investigations, showed the presence of a-synuclein (alpha-SYN) aggregates and neurotransmitter alterations in enteric tissues. All these findings support the Braak proposed model for the pathophysiology of alpha-SYN aggregates in PD, with early pathological involvement of the enteric nervous system and dorsal motor nucleus of the vagus. Therefore, constipation could have the potential sensitivity to be used as a clinical biomarker of the prodromal phase of the disease. The use of colonic biopsies to look at alpha-SYN pathology, once confirmed by larger prospective studies, might eventually represent a feasible, albeit partially invasive, new diagnostic biomarker for PD.
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Details
- Title
- Constipation: an emerging risk factor for Parkinson's disease?
- Creators
- P. Stirpe - Vita-Salute San Raffaele UniversityM. Hoffman - Drexel Univ, Coll Med, Philadelphia, PA 19104 USAD. Badiali - Sapienza University of RomeC. Colosimo - Santa Maria Nuova Hospital
- Publication Details
- European journal of neurology, v 23(11), pp 1606-1613
- Publisher
- Wiley
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000387367700007
- Scopus ID
- 2-s2.0-84991585251
- Other Identifier
- 991021864440504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences