Journal article
Constitutive modeling of compressible type-I collagen hydrogels
Medical engineering & physics, v 53, pp 39-48
01 Mar 2018
PMID: 29396019
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Abstract
Collagen hydrogels have been used ubiquitously as engineering biomaterials with a biphasic network of fibrillar collagen and aqueous-filled voids that contribute to a complex, compressible, and nonlinear mechanical behavior-not well captured within the infinitesimal strain theory. In this study, type-I collagen, processed from a bovine corium, was fabricated into disks at 2, 3, and 4% (w/w) and exposed to 0, 10(5), 10(5), and 10(7) microjoules of ultraviolet light or enzymatic degradation via matrix metalloproteinase-2. Fully hydrated gels were subjected to unconfined, aqueous, compression testing with experimental data modeled within a continuum mechanics framework by employing the uncommon Blatz-Ko material model for porous elastic materials and a nonlinear form of the Poisson's ratio. From the Generalized form, the Special Blatz-Ko, compressible Neo-Hookean, and incompressible Mooney-Rivlin models were derived and the best-fit material parameters reported for each. The average root-mean-squared (RMS) error for the General (RMS. 0.13 0.07) and Special Blatz-Ko (RMS= 0.13 0.07) were lower than the Neo-Hookean (RMS= 0.23 0.10) and Mooney-Rivlin (RMS= 0.18 0.08) models. We conclude that, with a single fitted-parameter, the Special Blatz-Ko sufficiently captured the salient features of collagen hydrogel compression over most examined formulations and treatments. (C) 2018 IPEM. Published by Elsevier Ltd. All rights reserved.
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Details
- Title
- Constitutive modeling of compressible type-I collagen hydrogels
- Creators
- Brooks A. Lane - University of South CarolinaKatrina A. Harmon - University of South CarolinaRichard L. Goodwin - University of South CarolinaMichael J. Yost - Medical University of South CarolinaTarek Shazly - University of South CarolinaJohn F. Eberth - University of South Carolina
- Publication Details
- Medical engineering & physics, v 53, pp 39-48
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- P20GM103499 / NIH South Carolina IDeA Networks of Biomedical Research Excellence (INBRE) P20GM103499 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000429510600004
- Scopus ID
- 2-s2.0-85040774762
- Other Identifier
- 991021902596204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical