Journal article
Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology
Journal of biomedical materials research. Part A, v 106(6), pp 1664-1676
01 Jun 2018
PMID: 29460433
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Articular cartilage (AC) has gradient features in both mechanics and histology as well as a poor regeneration ability. The repair of AC poses difficulties in both research and the clinic. In this paper, a gradient scaffold based on poly(lactic-co-glycolic acid) (PLGA)-extracellular matrix was proposed. Cartilage scaffolds with a three-layer gradient structure were fabricated by PLGA through three-dimensional printing, and the microstructure orientation and pore fabrication were made by decellularized extracellular matrix injection and directional freezing. The manufactured scaffold has a mechanical strength close to that of real cartilage. A quantitative optimization of the Young's modulus and shear modulus was achieved by material mechanics formulas, which achieved a more accurate mechanical bionic and a more stable interface performance because of the one-time molding process. At the same time, the scaffolds have a bionic and gradient microstructure orientation and pore size, and the stratification ratio can be quantitatively optimized by design of the freeze box and temperature simulation. In general, this paper provides a method to optimize AC scaffolds by both mechanics and histology as well as a bionic multimaterial scaffold. This paper is of significance for cell culture and clinical transplantation experiments. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1664-1676, 2018.
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Details
- Title
- Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology
- Creators
- Yuanyuan Xu - Biomanufacturing Engineering Laboratory; Graduate School at Shenzhen, Tsinghua University; Shenzhen Guangdong ChinaXiao Guo - Tsinghua Univ, Biomfg Engn Lab, Grad Sch Shenzhen, Shenzhen, Guangdong, Peoples R ChinaShuaitao Yang - Tsinghua UniversityLong Li - Shenzhen Institutes of Advanced TechnologyPeng Zhang - Shenzhen Institutes of Advanced TechnologyWei Sun - Tsinghua UniversityChangyong Liu - Manufacturing InstituteShengli Mi - Open FIESTA Center, Tsinghua University; Shenzhen Guangdong China
- Publication Details
- Journal of biomedical materials research. Part A, v 106(6), pp 1664-1676
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- JCYJ20150731154850925; JCYJ20160509154951210 / Basic of Shenzhen CXZZ20150529144128031; KQCX2015033117354152 / Shenzhen Science and Technology Innovation Committee
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000431004500020
- Scopus ID
- 2-s2.0-85043255522
- Other Identifier
- 991019167471404721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials