Journal article
Continuous Infusion 5-Fluorouracil with Bolus Adriamycin and Mitomycin and Low-Dose Cisplatin (FAMP) in the Treatment of Metastatic Gastric Carcinoma: An Evaluation of Efficacy and Toxicity
Cancer investigation, v 9(1)
1991
PMID: 2012996
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
A pilot study was performed to evaluate the feasability of administering prolonged continuous infusion 5-fluorouracil with multiple bolus chemotherapeutic agents. Twelve patients with advanced measurable gastric carcinoma were treated with a combination chemotherapy program of continuous infusion 5-fluorouracil, bolus Adriamycin, mitomycin C, and low-dose cisplatin (FAMP). Responses were observed in 5 patients (2 complete and 3 partial). Observed toxicities included leukopenia, thrombocytopenia, mucositis, and hand-foot syndrome. Although the FAMP regimen has activity in advanced gastric carcinoma, the number of patients evaluated was small and significant improvement over currently available regimens could not be demonstrated. Evaluation of toxicities indicates that bolus administration of multiple agents (specifically, Adriamycin, mitomycin C, and cisplatin) can be used in conjunction with continuously infused 5-fluorouracil without excessive toxicity.
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Details
- Title
- Continuous Infusion 5-Fluorouracil with Bolus Adriamycin and Mitomycin and Low-Dose Cisplatin (FAMP) in the Treatment of Metastatic Gastric Carcinoma: An Evaluation of Efficacy and Toxicity
- Creators
- James W. Raschko - Georgetown University Medical CenterElizabeth A. Johnson - Division of Medical Oncology, Lombardi Cancer Reseach Center, Georgetown University Hospital, Washington, DC, 20007Winston Ueno - Division of Medical Oncology, Lombardi Cancer Reseach Center, Georgetown University Hospital, Washington, DC, 20007Paul V. Woolley - Division of Medical Oncology, Lombardi Cancer Reseach Center, Georgetown University Hospital, Washington, DC, 20007Joseph Treat - Division of Medical Oncology, Lombardi Cancer Reseach Center, Georgetown University Hospital, Washington, DC, 20007Ebony A Johnson - Accelerated Career Entry Bachelor of Science in Nursing (BSN)
- Publication Details
- Cancer investigation, v 9(1)
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN)
- Web of Science ID
- WOS:A1991FH95700006
- Scopus ID
- 2-s2.0-0025730497
- Other Identifier
- 991019183984204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology