Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (166), e62050
Dec 2020
PMID: 33346203
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Noninvasive, accurate measurement of pressures within the human body has long been an important but elusive clinical goal. Contrast agents for ultrasound imaging are gas-filled, encapsulated microbubbles (diameter < 10 mu m) that traverse the entire vasculature and enhance signals by up to 30 dB. These microbubbles also produce nonlinear oscillations at frequencies ranging from the subharmonic (half of the transmit frequency) to higher harmonics. The subharmonic amplitude has an inverse linear relationship with the ambient hydrostatic pressure. Here an ultrasound system capable of performing real-time, subharmonic aided pressure estimation (SHAPE) is presented. During ultrasound contrast agent infusion, an algorithm for optimizing acoustic outputs is activated. Following this calibration, subharmonic microbubble signals (i.e., SHAPE) have the highest sensitivity to pressure changes and can be used to noninvasively quantify pressure. The utility of the SHAPE procedure for identifying portal hypertension in the liver is the emphasis here, but the technique has applicability across many clinical scenarios.
Metrics
Details
- Title
- Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
- Publication Details
- JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (166), e62050
- Publisher
- JOURNAL OF VISUALIZED EXPERIMENTS; CAMBRIDGE
- Grant note
- This work is supported in part by the U.S. Army Medical Research Material Command under W81XWH-08-1-0503, and W81XWH-12-1-0066, by AHA grants no 0655441U and 15SDG25740015 as well as by NIH R21 HL081892, R21 HL130899, R21 HL089175, RC1 DK087365, R01 DK098526, R01 DK118964, R01 CA140338, R01 CA234428, by Lantheus Medical Imaging and by GE Healthcare, Oslo, Norway.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000646166900051
- Scopus ID
- 2-s2.0-85097836448
- Other Identifier
- 991021860772104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging