Logo image
Back
Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients
Journal article   Open access   Peer reviewed

Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients

Ozen K Basoglu, Amir Pelleg, Sergei A Kharitonov and Peter J Barnes
Pulmonary pharmacology & therapeutics, v 45, pp 13-18
Aug 2017
DOI: https://doi.org/10.1016/j.pupt.2017.04.004
PMID: 28392320
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://hdl.handle.net/10044/1/52034View
SubmittedCC BY-NC-ND V4.0,  Open

Abstract

Adenosine Monophosphate - administration & dosage Adenosine Triphosphate - administration & dosage Adult Asthma - physiopathology Bronchial Hyperreactivity - etiology Bronchial Provocation Tests Bronchoconstriction - drug effects Capsaicin - administration & dosage Case-Control Studies Cough - epidemiology Cough - etiology Double-Blind Method Dyspnea - epidemiology Dyspnea - etiology Female Forced Expiratory Volume Humans Male Prospective Studies Smoking - epidemiology
Adenosine 5'-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting Aδ-fibres with rapidly adapting receptors (RARs). Pulmonary C-fibres but not RARs are also sensitive to capsaicin, a potent tussigenic agent in humans. Thus, the aim of this study was to determine the effects of ATP and its metabolite adenosine (given as adenosine 5'-monophosphate, AMP) on capsaicin challenge in asthmatic patients. Cough (quantified as visual analogue scale, VAS), dyspnoea (quantified as Borg score), and FEV were quantified following bronchoprovocation using capsaicin, adenosine and ATP in healthy non-smokers (age 40±4y, 6 males), smokers (45±4y, 5 males) and asthmatic patients (37±3y, 5 males); n = 10 in each group. None of the healthy non-smokers responded to either AMP or ATP. AMP induced bronchoconstriction in one smoker and eight asthmatics, and ATP in two smokers and all ten asthmatics. The geometric mean of capsaicin causing ≥5 coughs (C5) increased from 134 to 203 μM in non-smokers and from 117 to 287 μM in asthmatics after AMP, whereas it decreased from 203 to 165 μM and 125 to 88 μM, respectively after ATP. AMP decreased C5 from 58 to 29 μM and ATP increased from 33 to 47 μM in smokers. However, due to intergroup variability, these effects of ATP and AMP were not statistically significant (0.125 ≤ p ≤ 0.998). That notwithstanding, in healthy and asthmatic subjects the effects of the ATP showed a tendency to be greater than those of AMP (p < 0.053). Dyspnea, assessed by Borg score, increased after ATP (p < 0.001) and AMP (p < 0.001) only in asthmatic patients. Intensity of cough assessed by VAS increased (p < 0.05) after second capsaicin challenges performed after AMP in all groups, but not after ATP. Asthmatic patients exhibit hypersensitivity to aerosolized AMP and ATP, but aerosolized AMP does not mimic the effects of ATP and the effects of ATP are not mediated by adenosine.

Metrics

6 Record Views
18 citations in Web of Science
16 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Pharmacology & Pharmacy
Respiratory System
Logo image