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Journal article
Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study
Frontiers in bioengineering and biotechnology, v 10, pp 825149-825149
08 Apr 2022
PMID: 35464733
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mammalian locomotion is generated by central pattern generators (CPGs) in the spinal cord, which produce alternating flexor and extensor activities controlling the locomotor movements of each limb. Afferent feedback signals from the limbs are integrated by the CPGs to provide adaptive control of locomotion. Responses of CPG-generated neural activity to afferent feedback stimulation have been previously studied during fictive locomotion in immobilized cats. Yet, locomotion in awake, behaving animals involves dynamic interactions between central neuronal circuits, afferent feedback, musculoskeletal system, and environment. To study these complex interactions, we developed a model simulating interactions between a half-center CPG and the musculoskeletal system of a cat hindlimb. Then, we analyzed the role of afferent feedback in the locomotor adaptation from a dynamic viewpoint using the methods of dynamical systems theory and nullcline analysis. Our model reproduced limb movements during regular cat walking as well as adaptive changes of these movements when the foot steps into a hole. The model generates important insights into the mechanism for adaptive locomotion resulting from dynamic interactions between the CPG-based neural circuits, the musculoskeletal system, and the environment.
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Details
- Title
- Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study
- Creators
- Yongi Kim - Kyoto UniversityShinya Aoi - Kyoto UniversitySoichiro Fujiki - Dokkyo Medical UniversitySimon M. Danner - Drexel UniversitySergey N. Markin - Drexel UniversityJessica Ausborn - Drexel UniversityIlya A. Rybak - Drexel UniversityDai Yanagihara - University of TokyoKei Senda - Kyoto UniversityKazuo Tsuchiya - Kyoto University
- Publication Details
- Frontiers in bioengineering and biotechnology, v 10, pp 825149-825149
- Publisher
- Frontiers Media Sa
- Number of pages
- 13
- Grant note
- R01NS100928; R01NS110550; R01NS112304; R01NS115900 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 2113069 / NSF; National Science Foundation (NSF) JP19KK0377; JP20H00229; JP20KK0226 / JSPS KAKENHI; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI) JPMJFR2021 / JST; Japan Science & Technology Agency (JST)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000791957400001
- Scopus ID
- 2-s2.0-85128784874
- Other Identifier
- 991019167556804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Engineering, Biomedical