Journal article
Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants
Journal of perinatology, v 31(12), pp 749-756
Dec 2011
PMID: 21415837
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).
This is a retrospective cohort study of 114 infants <1000 g admitted to a level IV neonatal intensive care unit within 48 h of life. A cumulative, time-weighted glucose level (TWGL) derived from plotting glucose values over time was included in logistic regression analysis to identify predictors for severe ROP.
Infants had 26.6 ± 2 weeks gestational age and had a birth weight of 782 ± 136 g. TWGL during first 10 and 30 days of life were greater in the severe ROP group (P<0.01). Unlike single events of glucose levels ≥ 150 mg dl(-1), 10 days TWGL ≥ 100 mg dl(-1) (odds ratio (OR) 5.2, P<0.02) and 30 days TWGL ≥ 118 mg dl(-1) (OR 5.7, P<0.02) were predictors for severe ROP (univariate). Multivariate regression confirmed 30 days TWGL ≥ 118 mg dl(-1) (OR 9.4 to 10) and gram-positive sepsis (OR 4.1 to 5) as predictors for severe ROP (P<0.05).
High overall glycemic status is associated with the development of severe ROP.
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Details
- Title
- Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants
- Creators
- R Chavez-Valdez - Texas Tech University Health Sciences CenterJ McGowan - Drexel UniversityE Cannon - Texas Tech University Health Sciences CenterC U Lehmann - Johns Hopkins University
- Publication Details
- Journal of perinatology, v 31(12), pp 749-756
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000297646000002
- Scopus ID
- 2-s2.0-82455171901
- Other Identifier
- 991019169519004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics