Journal article
Control of streptozotocin diabetes in chinese hamsters by cultured mouse islet cells without immunosuppression: A preliminary report
The Journal of surgical research, v 28(1), pp 77-85
1980
PMID: 6767141
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cultured pancreas islet cells inside 50K hollow fibers were implanted into adult Chinese hamsters made diabetic with streptozotocin, either as isografts (hamster → hamster) or xenografts (mouse → hamster) with return to normoglycemia for a mean of 46.8 days in the xenografted and 52.3 days in the isografted animals. After the reappearance of the diabetic state, selected animals from both groups received a repeat transplant using a larger number of cells. These second implants maintained normoglycemia for a mean of 142 days (xenograft) and 230 days (isograft). Histological analysis of recovered implants showed a smooth fibroblastic covering with no white cell infiltration of the fibers.
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Details
- Title
- Control of streptozotocin diabetes in chinese hamsters by cultured mouse islet cells without immunosuppression: A preliminary report
- Creators
- Joy Archer - Hahnemann University HospitalRobert Kaye - Hahnemann University HospitalGeorge Mutter - Hahnemann University HospitalJohn H Archer - Pediatrics
- Publication Details
- The Journal of surgical research, v 28(1), pp 77-85
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1980JJ42000013
- Scopus ID
- 2-s2.0-0018872528
- Other Identifier
- 991019183967904721
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- Web of Science research areas
- Surgery