Journal article
Control theoretical concepts for synthetic and systems biology
Current opinion in systems biology, v 14, pp 50-57
Apr 2019
Abstract
Control theory, a branch of engineering devoted to the analysis and design of robust systems through feedback control, has been instrumental for many technological applications. It has been proposed that control theory is also a productive framework to analyze biological systems and advance their engineering. Examples confirming this perspective include the design of schemes of biomolecular sequestration to implement integral negative feedback for perfect disturbance rejection and the discovery of control theoretic trade-offs between stability and performance in the glycolytic pathway in Saccharomyces cerevisiae. Here, we briefly review some concepts and tools from classical feedback control theory that have been invoked in the study of biological systems and argue for the need to develop new control concepts specifically tailored to biology.
Metrics
13 Record Views
18 citations in Scopus
Details
- Title
- Control theoretical concepts for synthetic and systems biology
- Creators
- Ania-Ariadna Baetica - University of California, San FranciscoAlexandra Westbrook - University of California, San FranciscoHana El-Samad - University of California, San Francisco
- Publication Details
- Current opinion in systems biology, v 14, pp 50-57
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Scopus ID
- 2-s2.0-85063649237
- Other Identifier
- 991021889907404721