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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings
Biomaterials, v 196
Mar 2019
PMID: 30075952
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Older adults suffer from weakened and delayed bone healing due to age-related alterations in bone cells and in the immune system. Given the interaction between the immune system and skeletal cells, therapies that address deficiencies in both the skeletal and the immune system are required to effectively treat bone injuries of older patients. The sequence of macrophage activation observed in healthy tissue repair involves a transition from a pro-inflammatory state followed by a pro-reparative state. In older patients, inflammation is slower to resolve and impedes healing. The goal of this study was to design a novel drug delivery system for temporal guidance of the polarization of macrophages using bone grafting materials. A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNγ) from the pro-reparative stimulus simvastatin (SIMV). Effective doses were identified using a human monocyte line (THP-1) and testing culminated with bone marrow macrophages obtained from old mice. Sequential M1-to-M2 activation was achieved with both cell types. These results suggest that this novel immunomodulatory drug delivery system holds potential for controlling macrophage activation in bones of older patients.
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Details
- Title
- Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings
- Creators
- Jumana R. Alhamdi - University of Connecticut Health CenterTao Peng - University of Connecticut Health CenterIman M. Al-Naggar - University of Connecticut Health CenterKelly L. Hawley - Connecticut Children's Medical CenterKara L. Spiller - Drexel UniversityLiisa T. Kuhn - University of Connecticut Health Center
- Publication Details
- Biomaterials, v 196
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000459527700008
- Scopus ID
- 2-s2.0-85060107797
- Other Identifier
- 991019168458904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials