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Journal article
Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans
Biogerontology (Dordrecht), v 18(4), pp 485-497
01 Aug 2017
PMID: 28573417
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived. The "recent'' acquisition of an extended longevity and large body mass of some species of mammals present on the earth today suggests the possibility that similar cellular mechanisms have been influenced by the forces of natural selection to create a convergent evolution of longevity. Many cellular mechanisms are potentially relevant for extending longevity; in this assay, we review the literature focusing primarily on two cellular features: (1) the capacity for extensive cellular proliferation of differentiated cells, while maintaining genome stability; and (2) the capacity to detect DNA damage. We have observed that longevity and body mass are both positively linked to these cellular mechanisms and then used statistical tools to evaluate their relative importance. Our analysis suggest that the capacity for extensive cellular proliferation while maintaining sufficient genome stability, correlates to species body mass while the capacity to correctly identify the presence of DNA damage seems more an attribute of long-lived species. Finally, our data are in support of the idea that a slower development, allowing for better DNA damage detection and handling, should associate with longer life span.
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Details
- Title
- Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans
- Creators
- Eleonora Croco - University of BolognaSilvia Marchionni - University of BolognaGianluca Storci - University of BolognaMassimiliano Bonafe - University of BolognaClaudio Franceschi - University of BolognaThomas D. Stamato - Lankenau Institute for Medical ResearchChristian Sell - Drexel UniversityAntonello Lorenzini - University of Bologna
- Publication Details
- Biogerontology (Dordrecht), v 18(4), pp 485-497
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- RFO funding of University of Bologna R21AG039799 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG39799 / National Institutes of Health/National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000405778700005
- Scopus ID
- 2-s2.0-85027955684
- Other Identifier
- 991019168790204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Geriatrics & Gerontology