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Journal article
Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons
Journal of chemical neuroanatomy, v 52, pp 9-19
01 Sep 2013
PMID: 23651691
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Based on the importance of the locus coeruleus-norepinephrine (LC-NE) system and the dorsal raphe nucleus-serotonergic (DRN-5-HT) system in stress-related pathologies, additional understanding of brain regions coordinating their activity is of particular interest. One such candidate is the amygdalar complex, and specifically, the central nucleus (CeA), which has been implicated in emotional arousal and is known to send monosynaptic afferent projections to both these regions. Our present data using dual retrograde tract tracing is the first to demonstrate a population of amygdalar neurons that project in a collateralized manner to the LC and DRN, indicating that amygdalar neurons are positioned to coordinately regulate the LC and DRN, and links these brain regions by virtue of a common set of afferents. Further, we have also characterized the phenotype of a population of these collaterally projecting neurons from the amygdala as containing corticotropin releasing factor or dynorphin, two peptides heavily implicated in the stress response. Understanding the co-regulatory influences of this limbic region on 5HT and NE regions may help fill a gap in our knowledge regarding neural circuits impacting these systems and their adaptations in stress. (C) 2013 Elsevier B.V. All rights reserved.
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Details
- Title
- Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons
- Creators
- T. A. Retson - Jefferson Hospital for NeuroscienceE. J. Van Bockstaele - Thomas Jefferson University
- Publication Details
- Journal of chemical neuroanatomy, v 52, pp 9-19
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- R01MH040008 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) DA 009082; MH 40008 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R29DA009082 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission F30AA021637 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000325597300002
- Scopus ID
- 2-s2.0-84884153973
- Other Identifier
- 991021903403404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences