Journal article
Coping Behavior Causes Asymmetric Changes in Neuronal Activation in the Prefrontal Cortex and Amygdala
Synapse (New York, N.Y.), v 63(1)
Jan 2009
PMID: 18932226
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
When faced with an inescapable stressor, animals may engage in ‘coping’ behaviors, such as chewing inedible objects, that attenuate some physiological responses to the stressor. Previous evidence indicates that dopamine neurotransmission in the right prefrontal cortex is modulated by coping processes. Here we tested whether medial prefrontal cortical (mPFC) neuronal activation, as measured by Fos-immunoreactivity (Fos-ir), was altered in rats chewing inedible objects during exposure to novelty stress. We found that chewing caused an increase in Fos-ir that was selective for the right hemisphere of the mPFC along with a decrease in Fos-ir that was selective for the right central nucleus of the amygdala (CeA), a region that may regulate dopamine neurotransmission in mPFC. These observations suggest that coping during stress engages mPFC and CeA neuronal activity asymmetrically.
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Details
- Title
- Coping Behavior Causes Asymmetric Changes in Neuronal Activation in the Prefrontal Cortex and Amygdala
- Creators
- Thomas A Stalnaker - Psychology Department, University of Wisconsin-Madison, Madison, WisconsinRodrigo A España - Psychology Department, University of Wisconsin-Madison, Madison, WisconsinCraig W Berridge - Psychology Department, University of Wisconsin-Madison, Madison, Wisconsin
- Publication Details
- Synapse (New York, N.Y.), v 63(1)
- Publisher
- Wiley
- Grant note
- R01 DA010681-08 || DA / National Institute on Drug Abuse : NIDA K02 DA000389-09 || DA / National Institute on Drug Abuse : NIDA K02 DA000389-08 || DA / National Institute on Drug Abuse : NIDA R01 DA010681-09 || DA / National Institute on Drug Abuse : NIDA K02 DA000389-07 || DA / National Institute on Drug Abuse : NIDA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000261658400010
- Scopus ID
- 2-s2.0-58149523237
- Other Identifier
- 991014878158304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences