Journal article
Copper-Catalyzed Conjugate Additions to Isocyanoalkenes
Journal of organic chemistry, v 87(1), pp 488-497
07 Jan 2022
PMID: 34932341
Abstract
A copper iodide-Pyox complex catalyzes the first conjugate addition of diverse sulfur, nitrogen, and carbon nucleophiles to isocyanoalkenes. The anionic addition generates metalated isocyanoalkanes capable of SNi displacements, providing a rapid route to a series of functionalized, cyclic isocyanoalkanes. The Cu(I)I-Pyox complex efficiently catalyzes a first-in-class conjugate addition affording a range of complex, functionalized isocyanoalkanes that are otherwise challenging to synthesize while laying a foundation for catalytic reactions that maintain the isocyanide group.
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Details
- Title
- Copper-Catalyzed Conjugate Additions to Isocyanoalkenes
- Creators
- John-Paul R. Marrazzo - Drexel UniversityAllen Chao - Abzena, 360 George Patterson Boulevard, Bristol, Pennsylvania 19007, United StatesYajun Li - Fujian Institute of Research on the Structure of MatterFraser F. Fleming - Drexel University
- Publication Details
- Journal of organic chemistry, v 87(1), pp 488-497
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- 1953128 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000759551400041
- Scopus ID
- 2-s2.0-85122015051
- Other Identifier
- 991019168336104721