Journal article
Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative
The Journal of infectious diseases, v 230(4), pp 1004-1012
16 Oct 2024
PMID: 39102894
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent evidence challenges the belief that individuals who are Duffy-negative are resistant to Plasmodium vivax due to lacking the Duffy antigen receptor for chemokines. Erythrocyte-binding protein (EBP/DBP2) has shown moderate binding to Duffy-negative erythrocytes in vitro. Reticulocyte-binding protein 2b (RBP2b) interactions with transferrin receptor 1 suggest involvement in Duffy-negative infections. Gene copy number variations in PvDBP1, PvEBP/DBP2, and PvRBP2b were investigated in Duffypositive and Duffy-negative P vivax infections from Ethiopia. Among Duffy-positive samples, 34% displayed PvDBP1 duplications (Cambodian type). In Duffy-negative infections, 30% showed duplications, mostly Cambodian type. For PvEBP/ DBP2 and PvRBP2b, Duffy-positive samples exhibited higher duplication rates (1-8 copies for PvEBP/DBP2, 46%; 1-5 copies for PvRBP2b, 43%) as compared with Duffy-negative samples (20.8% and 26%, respectively). The range of copy number variations was lower in Duffy-negative infections. Demographic and clinical factors associated with gene multiplications in both Duffy types were explored, enhancing understanding of P vivax evolution in Africans who are Duffy negative.
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Details
- Title
- Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative
- Creators
- Kareen Pestana - Drexel UniversityAnthony Ford - University of North Carolina at CharlotteRei Rama - University of North Carolina at CharlotteBeka Abagero - Drexel UniversityDaniel Kepple - University of North Carolina at CharlotteJunya Tomida - University of North Carolina at CharlotteJean Popovici - Institut PasteurDelenasaw Yewhalaw - Jimma UniversityEugenia Lo - Drexel University
- Publication Details
- The Journal of infectious diseases, v 230(4), pp 1004-1012
- Publisher
- Oxford University Press
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001299797700001
- Scopus ID
- 2-s2.0-85206598484
- Other Identifier
- 991022192028204721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology