Journal article
Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer
International journal of molecular sciences, v 20(10), p2528
02 May 2019
PMID: 31126011
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
(1) Glycoproteins account for similar to 80% of proteins located at the cell surface and in the extracellular matrix. A growing body of evidence indicates that -L-fucose protein modifications contribute to breast cancer progression and metastatic disease. (2) Using a combination of techniques, including matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) based in cell and on tissue imaging and glycan sequencing using exoglycosidase analysis coupled to hydrophilic interaction ultra-high performance liquid chromatography (HILIC UPLC), we establish that a core-fucosylated tetra-antennary glycan containing a single N-acetyllactosamine (F(6)A4G4Lac1) is associated with poor clinical outcomes in breast cancer, including lymph node metastasis, recurrent disease, and reduced survival. (3) This study is the first to identify a single N-glycan, F(6)A4G4Lac1, as having a correlation with poor clinical outcomes in breast cancer.
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Details
- Title
- Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer
- Creators
- Harmin Herrera - Drexel UniversityTinslee Dilday - Medical University of South CarolinaAllison Uber - Medical University of South CarolinaDanielle Scott - Medical University of South CarolinaJoelle N. Zambrano - Medical University of South CarolinaMengjun Wang - Medical University of South CarolinaPeggi M. Angel - Medical University of South CarolinaAnand S. Mehta - Medical University of South CarolinaRichard R. Drake - Medical University of South CarolinaElizabeth G. Hill - Medical University of South CarolinaElizabeth S. Yeh - Medical University of South Carolina
- Publication Details
- International journal of molecular sciences, v 20(10), p2528
- Publisher
- Mdpi
- Number of pages
- 15
- Grant note
- P30 CA138313 / Biostatistics Shared Resource, Hollings Cancer Center, Medical University of South Carolina NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R25GM072643 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Medical University of South Carolina South Carolina Centers of Economic Excellence P20 GM103542 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30 CA138313 / Hollings Cancer Center's Cancer Center at the Medical University of South Carolina UL1 TR001450 / NIH/NCATS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) South Carolina Clinical and Translational Research (SCTR) Institute
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000471001400159
- Scopus ID
- 2-s2.0-85066955565
- Other Identifier
- 991019318934804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary