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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement
Bioorganic & medicinal chemistry letters, v 26(1), pp 228-234
01 Jan 2016
PMID: 26531151
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
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Demand remains for new inhibitors of HIV-1 replication and the inhibition of HIV-1 entry is an extremely attractive therapeutic approach. Using field-based bioisosteric replacements, we have further extended the chemotypes available for development in the HIV-1 entry inhibitor class. Moreover, using field-based disparity analysis of the compounds, 3D structure–activity relationships were derived that will be useful in the further development of these inhibitors towards clinical utility.
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Details
- Title
- Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement
- Creators
- Marina Tuyishime - Drexel UniversityRae Lawrence - Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, UK.Simon Cocklin - Drexel University
- Publication Details
- Bioorganic & medicinal chemistry letters, v 26(1), pp 228-234
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000366161600043
- Scopus ID
- 2-s2.0-84949551304
- Other Identifier
- 991019167322104721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic