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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Clinical neuropsychologist, v 29(4), pp 466-486
19 May 2015
PMID: 25978342
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To identify approximately 500 cases of incident cognitive impairment (ICI) in a large, national sample adapting an existing cognitive test-based case definition and to examine relationships of vascular risk factors with ICI. Method: Participants were from the REGARDS study, a national sample of 30,239 African-American and White Americans. Participants included in this analysis had normal cognitive screening and no history of stroke at baseline, and at least one follow-up cognitive assessment with a three-test battery (TTB). Regression-based norms were applied to TTB scores to identify cases of ICI. Logistic regression was used to model associations with baseline vascular risk factors. Results: We identified 495 participants with ICI of 17,630 eligible participants. In multivariable modeling, income (OR 1.83 CI 1.27,2.62), stroke belt residence (OR 1.45 CI 1.18,1.78), history of transient ischemic attack (OR 1.90 CI 1.29,2.81), coronary artery disease(OR 1.32 CI 1.02,1.70), diabetes (OR 1.48 CI 1.17,1.87), obesity (OR 1.40 CI 1.05,1.86), and incident stroke (OR 2.73 CI 1.52,4.90) were associated with ICI. Conclusions: We adapted a previously validated cognitive test-based case definition to identify cases of ICI. Many previously identified risk factors were associated with ICI, supporting the criterion-related validity of our definition.
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Details
- Title
- Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
- Creators
- Sarah R. Gillett - University of VermontEvan L. Thacker - Brigham Young UniversityAbraham J. Letter - University of Alabama at BirminghamLeslie A. McClure - University of Alabama at BirminghamVirginia G. Wadley - University of Alabama at BirminghamFrederick W. Unverzagt - Indiana UniversityBrett M. Kissela - University of CincinnatiRichard E. Kennedy - University of Alabama at BirminghamStephen P. Glasser - University of Alabama at BirminghamDeborah A. Levine - University of Michigan–Ann ArborMary Cushman - University of Vermont
- Publication Details
- Clinical neuropsychologist, v 29(4), pp 466-486
- Publisher
- Routledge
- Grant note
- U01 NS041588 / National Institute of Neurological Disorders and Stroke (10.13039/100000065) R01 HL080477; T32 HL07594-24 / National Heart, Lung, and Blood Institute (10.13039/100000050)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000357935100006
- Scopus ID
- 2-s2.0-84937730121
- Other Identifier
- 991019231741404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Psychology
- Psychology, Clinical