Journal article
Correlation of Polymorphonuclear Cell Burden and Microbial Growth to the Inflammatory Cytokines in Tracheal Aspirates from Ventilated Preterm Infants
American journal of perinatology, v 41(10), pp 1388-1395
Jul 2024
PMID: 36773600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The significance of the presence of microorganisms and polymorphonuclear cells in the tracheal aspirates (TAs) of ventilated preterm infants is not well known. Our aim was to correlate information about the presence of polymorphonuclear cells with microbial growth and the cytokine milieu in the TAs of infants who have been intubated for >7 days.
TAs were collected from infants who had been intubated for 7 days or longer. Respiratory cultures were performed, and infants were stratified based on the presence and abundance of polymorphonuclear cells and microbial growth. Cytokines were measured in the TAs of each of the respective groups.
In the 19 infants whose TAs were collected, the presence of at least moderate WBC with presence of microbial growth was positively associated with the presence of interleukin (IL)-10, IL-1β, IL-8, and tumor necrosis factor (TNF)-α. The presence of at least moderate WBC, with or without microbial growth, was correlated positively with the presence of IL-8 and TNF-α.
There are higher levels of proinflammatory cytokines (especially, IL-10, IL-1β, and TNF-α) in TAs with higher cell counts and presence of microbial growth. The findings suggest that the presence of microbial growth correlated with inflammatory burden and warrant a larger study to see if treatment of microbial growth can ameliorate the inflammatory burden.
· Concomitant evaluation of inflammatory cells, microbial growth, and cytokines in tracheal aspirates..
· Moderate TA WBC with presence of microbial growth associated with IL-10, IL-1β, IL-8, and TNF-α..
· Moderate TA WBC, with/without microbial growth, correlated with the presence of IL-8 and TNF-α..
· Higher levels of IL-10, IL-1β, and TNF-α correlated with higher TA cell counts and microbial growth..
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Details
- Title
- Correlation of Polymorphonuclear Cell Burden and Microbial Growth to the Inflammatory Cytokines in Tracheal Aspirates from Ventilated Preterm Infants
- Creators
- Sophia Baig - Drexel UniversityPragnya Das - Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, PennsylvaniaNiharika Podaralla - St. Christopher's Hospital for ChildrenAlan Evangelista - Department of Pathology & Laboratory Medicine, Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, PennsylvaniaIshminder Kaur - Section of Infectious Diseases, Department of Pediatrics, Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, PennsylvaniaVineet Bhandari - Drexel University, Pediatrics
- Publication Details
- American journal of perinatology, v 41(10), pp 1388-1395
- Publisher
- Thieme
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000945989100004
- Scopus ID
- 2-s2.0-85159360623
- Other Identifier
- 991021861294204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics