Journal article
Correlation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas
Human pathology, v 66, pp 86-92
01 Aug 2017
PMID: 28300575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study the histologic grade of dedifferentiated liposarcomas was correlated with outcome in surgically resected specimens in 55 patients over a 19-year period at the University of Pittsburgh Medical Center. The tumors were located in the retroperitoneum (N=35); the extremities and thigh (N=16), and the remainder involved the spermatic cord and head and neck. Most tumors were large (mean=21 cm.) Follow-up was available in all 55 patients (median=36 months). Forty-one tumors classified as high-grade dedifferentiated liposarcoma (HG-DDLPS) had mitotically active pleomorphic and spindle cells and foci of necrosis. They included tumors with foci of smooth muscle differentiation (N=12), osteosarcoma (N=4), and myxoid areas (N=9). Fourteen tumors classified as low-grade dedifferentiated liposarcoma (LG-DDLPS) displayed a predominantly bland, monomorphic, spindle cell population with few mitoses and scant necrosis. The Kaplan–Meier method and log-rank test were used for statistical analysis. All tumors had unequivocal foci of well-differentiated liposarcoma (WDLPS). Fluorescence in situ hybridization (FISH) detected amplification of MDM2 in 29 cases. Twenty of 41 patients (49%) with HG-DDLPS died of tumor, and two patients died with LG-DDLPS (14%). The overall survival of patients with LG-DDLPS was significantly longer (P=.02). The median survival was 113 months for the LG-DDLPS and 48 months for the HG-DDLPS. Metastases (N=4) occurred only in the high-grade tumors and were independent of the type of heterologous differentiation. Patients with HG-DDLPS were at a greater risk of earlier death. Distinction between the two groups is important for patient selection for possible adjuvant therapy.
•Dedifferentiated liposarcomas were separated into low- and high-grade groups.•Cases with high histological grade correlated with poor clinical outcome.•Ample sampling and ancillary tests are useful in establishing the diagnosis.
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Details
- Title
- Correlation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas
- Creators
- Kossivi Dantey - UPMC PresbyterianKaren Schoedel - UPMC PresbyterianOleksandr Yergiyev - UPMC PresbyterianDavid Bartlett - UPMC PresbyterianUma N.M. Rao - UPMC Presbyterian
- Publication Details
- Human pathology, v 66, pp 86-92
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000411911000010
- Scopus ID
- 2-s2.0-85026863588
- Other Identifier
- 991021930444304721
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- Web of Science research areas
- Pathology