Journal article
Correlation of near infrared absorption and diffuse reflectance spectroscopy scattering with tissue neovascularization and collagen concentration in a diabetic rat wound healing model
Wound repair and regeneration, v 16(2)
01 Mar 2008
PMID: 18318809
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this paper was to correlate optical changes of tissue during wound healing measured by near infrared (NIR) and diffuse reflectance spectroscopy (DRS) with histologic changes in an animal model. Amplitude and phase of scattered light were obtained in a diabetic rat and control model and biopsies were taken for blood vessel ingrowth and collagen concentration. NIR absorption coefficient correlated with blood vessel ingrowth over time, in both the control and diabetic animals. DRS data correlated with collagen concentration. Previous publications by this group documented only the NIR changes during the wound healing process but this is the first reported correlation with histology data. The ability to correlate DRS scattering with collagen concentration during healing is another important and novel finding. This technology may play an important role clinically in assessing the efficacy of wound healing agents in diabetics.
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Details
- Title
- Correlation of near infrared absorption and diffuse reflectance spectroscopy scattering with tissue neovascularization and collagen concentration in a diabetic rat wound healing model
- Creators
- Michael S. Weingarten - Drexel UniversityElisabeth S. Papazoglou - Drexel UniversityLeonid Zubkov - Drexel UniversityLinda Zhu - Drexel UniversityMichael Neidrauer - Drexel UniversityGuy Savir - Drexel UniversityKim Peace - Drexel UniversityJohn G. Newby - University System of Maryland at HagerstownKambiz Pourrezaei - Drexel University
- Publication Details
- Wound repair and regeneration, v 16(2)
- Publisher
- Wiley
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000253761000013
- Scopus ID
- 2-s2.0-40349091706
- Other Identifier
- 991019168584204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Dermatology
- Medicine, Research & Experimental
- Surgery