Journal article
Correlation of volumetric magnetization transfer imaging with clinical data in MS
Neurology, v 50(6), pp 1609-1617
Jun 1998
PMID: 9633701
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined the relations between quantitative volumetric estimates of cerebral lesion load based on magnetization transfer imaging (MTI), clinical data, and measures of neuropsychological function in 44 patients with clinically diagnosed MS. In this population we assessed the correlation between several volumetric MTI measures, measures of neurologic function (Kurtzke Expanded Disability Status Scale and Ambulation Index), and disease duration using Spearman's correlation coefficient. Patients were classified on the basis of neuropsychological test performance as severely impaired, moderately impaired, and normal. We assessed differences between these groups with respect to MTI results using the Kruskal-Wallis test. MTI measures corrected for brain volume were found to correlate with disease duration (p < 0.01) and showed suggestive correlations with measures of neurologic impairment (p < 0.05). Individual neuropsychological tests correlated with MTI measures corrected and not corrected for brain volume (p < 0.001). An MTI measure not corrected for brain volume differed (p < 0.05) between severely impaired, moderately impaired, and normal patients. These preliminary results suggest that volumetric MTI analysis provides new measures that reflect more accurately the global lesion load in the brain of MS patients, and they may serve as a method to study the natural course of the disease and as an outcome measure to evaluate the effect of drugs.
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Details
- Title
- Correlation of volumetric magnetization transfer imaging with clinical data in MS
- Creators
- M A van Buchem - Hospital of the University of PennsylvaniaR I GrossmanC ArmstrongM PolanskyY MikiF H HeyningM P Boncoeur-MartelL WeiJ K UdupaM GrossmanD L KolsonJ C McGowan
- Publication Details
- Neurology, v 50(6), pp 1609-1617
- Grant note
- R01 NS2 9029-01 A1 / NINDS NIH HHS 5M01-RR00040 / NCRR NIH HHS R29 NS34353 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000074226700016
- Scopus ID
- 2-s2.0-0031747874
- Other Identifier
- 991019168222404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology