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Journal article
Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16(INK4a)
GeroScience, v 40(2), pp 193-199
01 Apr 2018
PMID: 29651745
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examined the correlation with age of two key proteins involved in the senescence program, p16(INK4a) and HMGB2. These proteins are involved in cell cycle arrest and chromatin remodeling during senescence. Circulating levels of these markers increases with age and correlates with functional status. The levels of HMGB2 appear to be significantly correlated with functional status, whereas p16(INK4a) levels are more weakly associated. Interestingly. there is a strong correlation between the two proteins independent of age. In particular, a single high-functioning individual over 90 years of age displays a disproportionately low level of HGMB2. The results suggest that with improved testing methodology, it may be possible to monitor circulating protein markers of senescence in human populations.
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Details
- Title
- Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16(INK4a)
- Creators
- Ibiyonu Lawrence - Drexel UniversityMichael Bene - Drexel UniversityTimothy Nacarelli - Drexel UniversityAshley Azar - Drexel UniversityJustin Z. Cohen - Drexel UniversityClaudio Torres - Drexel UniversityGregg Johannes - Drexel UniversityChristian Sell - Drexel University
- Publication Details
- GeroScience, v 40(2), pp 193-199
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- R01 NS078283 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) F31 AG054191 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01NS078283 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) F31AG054191 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000433040100009
- Scopus ID
- 2-s2.0-85045279244
- Other Identifier
- 991019168537904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology