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Cortical up and activated states: implications for sensory information processing
Journal article   Open access   Peer reviewed

Cortical up and activated states: implications for sensory information processing

Manuel A Castro-Alamancos
The Neuroscientist (Baltimore, Md.), v 15(6), pp 625-634
Dec 2009
PMID: 19321459
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701994View
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Sensation - physiology Synaptic Transmission - physiology Humans Nerve Net - physiology Action Potentials - physiology Arousal - physiology Animals Biological Clocks - physiology Sensory Receptor Cells - physiology Nerve Net - anatomy & histology Thalamus - physiology Cerebral Cortex - physiology Cerebral Cortex - anatomy & histology
The neocortex generates spontaneous slow oscillations that consist of up and down states during quiescence. Up states are short epochs of persistent activity that resemble the state of cortical activation during arousal and cognition. The excitability of cortical cells and synaptic networks is impacted by up states. This review describes the characteristics and putative functional role of up states and their similarity with activated states.

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Web of Science research areas
Clinical Neurology
Neurosciences
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