Journal article
Corticosteroids for Everyone with Meningitis?
The New England journal of medicine, v 347(20), pp 1613-1615
14 Nov 2002
PMID: 12432049
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In 1988, a landmark study was reported on the use of adjunctive treatment with dexamethasone in infants and children who had bacterial meningitis.
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The rationale for this study was based on studies involving animal models of bacterial meningitis, which demonstrated that the subarachnoid-space inflammatory response was a major factor contributing to morbidity and mortality among patients with this disorder. This inflammatory response is generated through local release by the central nervous system of proinflammatory mediators such as interleukin-1 and tumor necrosis factor in response to lysis of meningeal pathogens induced by antimicrobial agents. The consequences of this inflammatory response were . . .
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Details
- Title
- Corticosteroids for Everyone with Meningitis?
- Creators
- W. Michael ScheldAllan R Tunkel
- Publication Details
- The New England journal of medicine, v 347(20), pp 1613-1615
- Publisher
- Massachusetts Medical Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:000179187800010
- Scopus ID
- 2-s2.0-0037079042
- Other Identifier
- 991019346722404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal