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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Corticostriatal circuitry and habitual ethanol seeking
Alcohol (Fayetteville, N.Y.), v 49(8), pp 817-824
01 Dec 2015
PMID: 26059221
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of alcohol-use disorders is thought to involve a transition from casual alcohol use to uncontrolled alcohol-seeking behavior. This review will highlight evidence suggesting that the shift toward inflexible alcohol seeking that occurs across the development of addiction consists, in part, of a progression from goal-directed to habitual behaviors. This shift in "response strategy" is thought to be largely regulated by corticostriatal network activity. Indeed, specific neuroanatomical substrates within the prefrontal cortex and the striatum have been identified as playing opposing roles in the expression of actions and habits. A majority of the research on the neurobiology of habitual behavior has focused on non-drug reward seeking. Here, we will highlight recent research identifying corticostriatal structures that regulate the expression of habitual alcohol seeking and a comparison will be made when possible to findings for non-drug rewards.
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Details
- Title
- Corticostriatal circuitry and habitual ethanol seeking
- Creators
- Jacqueline M. Barker - Medical University of South CarolinaLaura H. Corbit - The University of SydneyDonita L. Robinson - University of North Carolina at Chapel HillChristina M. Gremel - University of California San DiegoRueben A. Gonzales - The University of Texas at AustinL. Judson Chandler - Medical University of South Carolina
- Publication Details
- Alcohol (Fayetteville, N.Y.), v 49(8), pp 817-824
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- P50AA010761; R01AA018008; F32AA023141; R01AA011852; R29AA010983; R00AA021780; R01AA010983; T32AA007474; F31AA020135; R37AA011852 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) AA071581 / NIAAA Conference Grant AA007474; AA023141; AA010761; AA010983; AA11852; AA018008 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1051037 / Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia DICBR NIAAA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000367421400008
- Scopus ID
- 2-s2.0-84983122321
- Other Identifier
- 991020100200304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Substance Abuse
- Toxicology