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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Costimulation signals for memory CD8+ T cells during viral infections
Critical reviews in immunology, v 29(6), pp 469-486
2009
PMID: 20121696
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Costimulation signals have been recognized as critical for optimal T-cell responses and result from important interactions between receptors on the surface of T cells and their ligands on antigen-presenting cells. Two families of receptors, the CD28 family and the tumor necrosis factor receptor (TNFR) family, have been found to be major players in providing costimulation to CD8+ T cells. Recent studies using viral infection models have highlighted the importance of CD28 costimulation signals during memory responses against viruses. Programmed death-1 (PD-1), another member of the CD28 family, may contribute to functional defects of helpless memory CD8+ T cells. Members of the TNFR family, such as CD27, 4-1BB, CD40, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), and OX40, have also been implicated in the survival, generation, maintenance, and quality of virus-specific memory CD8+T cells. The delivery of costimulatory molecules such as CD28, 4-1BB, and OX40 can help boost the generation and function of virus-specific memory CD8+ T cells. The use of costimulatory molecules as adjuvants, along with viral antigens in vaccines, may facilitate the generation of effective antigen-specific memory CD8+ T-cell responses. Understanding the costimulatory requirements of memory CD8+ T cells, therefore, may lead to improved vaccines that target anti-viral CD8+ T-cell memory.
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Details
- Title
- Costimulation signals for memory CD8+ T cells during viral infections
- Creators
- Priyanka A Duttagupta - Drexel UniversityAlina C Boesteanu - Drexel UniversityPeter D Katsikis - Drexel University
- Publication Details
- Critical reviews in immunology, v 29(6), pp 469-486
- Grant note
- R01 AI66215 / NIAID NIH HHS R01 AI066215 / NIAID NIH HHS R01 AI046719 / NIAID NIH HHS R01 AI046719-11 / NIAID NIH HHS R01 AI46719 / NIAID NIH HHS R01 AI066215-05 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000274695900002
- Scopus ID
- 2-s2.0-76749152267
- Other Identifier
- 991019339578004721
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- Web of Science research areas
- Immunology