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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Covalent Attachment of P15 Peptide to Ti Alloy Surface Modified with Polymer to Enhance Osseointegration of Implants
ACS applied materials & interfaces, v 11(42), pp 38531-38536
23 Oct 2019
PMID: 31599570
Abstract
Titanium (Ti) and its alloys are used in orthopedic and dental implants due to their excellent physical properties and biocompatibility. Although Ti exhibits superior osteoconductive properties compared to those of polymer-based implants, improved bone-on growth properties are required for enhanced surgical outcomes and improved recovery surgical interventions. Herein, we demonstrate a novel surface modification strategy to enhance the osteoconductivity of Ti surfaces through the grafting-from procedure of a reactive copolymer via surface-initiated atom transfer radical polymerization (SI-ATRP). Then, postpolymerization conjugation of the P15 peptide, an osteoblast binding motif, was successfully carried out. Subsequent in vitro studies revealed that the surface modification promoted osteoblast attachment on the Ti discs at 6 and 24 h. Moreover, mineral matrix deposition by osteoblasts was greater for the surface-modified Ti than for plain Ti and P15 randomly absorbed onto the Ti surface. These results suggest that the strategy for postpolymerization incorporation of P15 onto a Ti surface with a polymer interface may provide improved osseointegration outcomes, leading to enhanced quality of life for patients.
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Details
- Title
- Covalent Attachment of P15 Peptide to Ti Alloy Surface Modified with Polymer to Enhance Osseointegration of Implants
- Creators
- Liye Fu - Carnegie Mellon UniversityMaiko Omi - University of Michigan–Ann ArborMingkang Sun - Carnegie Mellon UniversityBoyle Cheng - Allegheny Health NetworkGordon Mao - Allegheny Health NetworkTong Liu - Carnegie Mellon UniversityGustavo Mendonça - University of Michigan–Ann ArborSaadyah E Averick - Allegheny Health NetworkYuji Mishina - University of Michigan–Ann ArborKrzysztof Matyjaszewski - Carnegie Mellon University
- Publication Details
- ACS applied materials & interfaces, v 11(42), pp 38531-38536
- Publisher
- American Chemical Society
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Neurosurgery
- Web of Science ID
- WOS:000492802100017
- Scopus ID
- 2-s2.0-85073168059
- Other Identifier
- 991021930448804721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology