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Cracking the Code: A Case Report on Low-Renin Hypertension
Journal article   Open access   Peer reviewed

Cracking the Code: A Case Report on Low-Renin Hypertension

Fawwad A. Ansari, Bilal Hamid, Inemesit Akpan, Ghida Akhdar and Muhammad Umer Riaz Gondal
Curēus (Palo Alto, CA), v 16(7), 65335
25 Jul 2024
PMID: 39184766
url
https://doi.org/10.7759/cureus.65335View
Published, Version of Record (VoR) Open

Abstract

General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology
Low-renin hypertension (LRH) is characterized by hypertension accompanied by low serum renin levels. LRH is a spectrum, including low-renin essential hypertension (LREH), primary hyperaldosteronism, and several acquired or familial secondary forms. Here, we present a case of LRH. A 57-year-old female with resistant hypertension on multiple antihypertensive medications presented for blood pressure management. Workup for secondary causes of hypertension revealed low renin levels with normal aldosterone. The patient was initiated on spironolactone and responded quickly with normal blood pressure on a follow-up visit. LRH is an under-recognized etiology for uncontrolled hypertension. It can be secondary to several different causes. Although treatment of LREH is essentially the same as regular patients, these patients tend to respond well to sodium-volume-depleting diuretics, mineralocorticoid receptor blockers, and epithelial sodium channels (ENaC) blockers.

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International collaboration
Web of Science research areas
Peripheral Vascular Disease
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