Journal article
Critical interval for rescue of axotomized neurons by transplants
Neuroreport, v 9(1)
05 Jan 1998
PMID: 9592039
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
TO determine whether embryonic spinal cord transplants retained the ability to prevent retrograde death of Clarkeʼs nucleus (CN) neurons if supplied after a delay, we hemisected adult rats at the T8 spinal cord segment and placed transplants of fetal tissue into the hemisection cavity immediately or up to 14 days later. Transplants provided in the first 7 days after injury prevented virtually all of the 30% loss of CN neurons at L1 ipsilateral to hemisection that occurs without a transplant. Transplants supplied at 14 days post-hemisection were ineffective. Because prevention of retrograde neuron death is one mechanism by which transplants may contribute to locomotor recovery after spinal cord injury, this window of effectiveness should be considered in the design of clinical trials.
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Details
- Title
- Critical interval for rescue of axotomized neurons by transplants
- Creators
- Motohide Shibayama - 1Department of Anatomy and Neurobiology, Allegheny University of the Health Sciences, 3200 Henry Ave., Philadelphia, PA 19129, USA 2Department of Orthopedic Surgery, Nagoya City Univ. School of Medicine, Nagoya, Aichi, Japan 3Department of Veterans Affairs Hospital, Philadelphia, PA 19104, USANobuo MatsuiB HimesMarion MurrayAlan Tessler
- Publication Details
- Neuroreport, v 9(1)
- Publisher
- Lippincott-Raven Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000071498600005
- Scopus ID
- 2-s2.0-0032484633
- Other Identifier
- 991014878209904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences