Journal article
Cross-Linked Amyloid beta-Protein Oligomers: A Missing Link in Alzheimer's Disease Pathology?
The journal of physical chemistry. B, v 125(5), pp 1307-1316
11 Feb 2021
PMID: 33440940
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Amyloid beta-protein (A beta) oligomers are broadly viewed as the proximate mediators of toxicity in Alzheimer's disease (AD). Recent studies, however, provide substantial evidence that A beta is involved in protection and repair of the central nervous system whereby A beta oligomer and subsequent fibril formation are integral to its normal antimicrobial and antiviral function. These developments raise a question of what exactly makes A beta oligomers toxic in the context of AD. This Perspective describes a paradigm shift in the search for toxic A beta oligomer species that involves oxidative-stress-induced stabilization of A beta oligomers via cross-linking and reviews most recent research elucidating structural aspects of cross-linked A beta oligomers and potential inhibition of their toxicity.
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Details
- Title
- Cross-Linked Amyloid beta-Protein Oligomers: A Missing Link in Alzheimer's Disease Pathology?
- Creators
- Brigita Urbanc - Drexel University
- Publication Details
- The journal of physical chemistry. B, v 125(5), pp 1307-1316
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000619747900001
- Scopus ID
- 2-s2.0-85099993997
- Other Identifier
- 991019169102204721
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- Web of Science research areas
- Chemistry, Physical