Journal article
Cross-sectional and longitudinal associations of neighborhood characteristics with inflammatory markers: Findings from the multi-ethnic study of atherosclerosis
Health & place, v 16(6), pp 1104-1112
2010
PMID: 20667763
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We investigated cross-sectional associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (
n=5370) and longitudinal associations with changes in IL-6 over a 3–4 year period (
n=946). In cross-sectional analyses, higher levels of neighborhood deprivation and problems were associated with higher levels of all three inflammatory markers, whereas higher levels of safety were associated with lower levels. Fibrinogen remained associated with all neighborhood characteristics except cohesion and IL-6 remained associated with safety after adjustment for race and SES. In longitudinal analyses, higher levels of neighborhood deprivation and problems, and lower levels of safety were associated with greater longitudinal increases in IL-6 after adjustment for age, sex, race, and SES. These findings were not substantially modified by further risk factor adjustment. Although findings regarding different inflammatory markers were mixed, the longitudinal results that are less limited by race confounding suggest that inflammatory pathways may contribute to neighborhood differences in cardiovascular disease risk.
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Details
- Title
- Cross-sectional and longitudinal associations of neighborhood characteristics with inflammatory markers: Findings from the multi-ethnic study of atherosclerosis
- Creators
- Aydin Nazmi - University of MichiganAna Diez Roux - University of MichiganNalini Ranjit - University of MichiganTeresa E Seeman - University of California, Los AngelesNancy S. Jenny - University of Vermont
- Publication Details
- Health & place, v 16(6), pp 1104-1112
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000284135900005
- Scopus ID
- 2-s2.0-77957682234
- Other Identifier
- 991020112078904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health