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Journal article
Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
Nature communications, v 8(1), pp 1011-10
24 Oct 2017
PMID: 29066808
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Integration of emerging epigenetic information with autism spectrum disorder (ASD) genetic results may elucidate functional insights not possible via either type of information in isolation. Here we use the genotype and DNA methylation (DNAm) data from cord blood and peripheral blood to identify SNPs associated with DNA methylation (meQTL lists). Additionally, we use publicly available fetal brain and lung meQTL lists to assess enrichment of ASD GWAS results for tissue-specific meQTLs. ASD-associated SNPs are enriched for fetal brain (OR = 3.55; P < 0.001) and peripheral blood meQTLs (OR = 1.58; P < 0.001). The CpG targets of ASD meQTLs across cord, blood, and brain tissues are enriched for immunerelated pathways, consistent with other expression and DNAm results in ASD, and reveal pathways not implicated by genetic findings. This joint analysis of genotype and DNAm demonstrates the potential of both brain and blood-based DNAm for insights into ASD and psychiatric phenotypes more broadly.
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Details
- Title
- Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
- Creators
- Shan V. Andrews - Johns Hopkins UniversityShannon E. Ellis - Johns Hopkins UniversityKelly M. Bakulski - University of Michigan–Ann ArborBrooke Sheppard - Johns Hopkins UniversityLisa A. Croen - Kaiser PermanenteIrva Hertz-Picciotto - MIND InstituteCraig J. Newschaffer - Drexel UniversityAndrew P. Feinberg - Johns Hopkins MedicineDan E. Arking - BloombergChristine Ladd-Acosta - BloombergM. Daniele Fallin - Bloomberg
- Publication Details
- Nature communications, v 8(1), pp 1011-10
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- R01ES016443; R01ES019001; R01ES017646 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01ES017646 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 260377; 7659 / Autism Speaks U10DD000180; U10DD000181; U10DD000182; U10DD000183; U10DD000184; U10DD000498 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA Burroughs-Wellcome Trust training grant: Maryland, Genetics, Epidemiology and Medicine (MD-GEM) U01DD001214 / National Center on Birth Defects and Developmental Disabilities; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000413565600001
- Scopus ID
- 2-s2.0-85032195304
- Other Identifier
- 991019168243904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity