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Current Use for Old Antibacterial Agents: Polymyxins, Rifamycins, and Aminoglycosides
Journal article   Peer reviewed

Current Use for Old Antibacterial Agents: Polymyxins, Rifamycins, and Aminoglycosides

Luke F. Chen and Donald Kaye
Infectious disease clinics of North America, v 23(4), pp 1053-1075
2009
DOI: https://doi.org/10.1016/j.idc.2009.06.004
PMID: 19909897
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Aminoglycoside Pharmacodynamics Pharmacokinetics Polymyxins Rifampin Rifaximin Toxicity
This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infections, especially those involving foreign bodies. Rifaximin is a new rifamycin that is a strict enteric antibiotic approved for treatment of traveler's diarrhea and is showing promise as a possible agent for refractory Clostridium difficile infections. The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis.

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50 citations in Web of Science
54 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
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