Journal article
Current approaches to enhance glutamate transporter function and expression
Journal of neurochemistry, v 134(6), pp 982-1007
01 Sep 2015
PMID: 26096891
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
L-glutamate is the predominant excitatory neurotransmitter in the qCNS and has a central role in a variety of brain functions. The termination of glutamate neurotransmission by excitatory amino acid transporters (EAATs) is essential to maintain glutamate concentration low in extracellular space and avoid excitotoxicity. EAAT2/GLT-1, being the most abundant subtype of glutamate transporter in the CNS, plays a key role in regulation of glutamate transmission. Dysfunction of EAAT2 has been correlated with various pathologies such as traumatic brain injury, stroke, amyotrophic lateral sclerosis, Alzheimer's disease, among others. Therefore, activators of the function or enhancers of the expression of EAAT2/GLT-1 could serve as a potential therapy for these conditions. 1Translational activators of EAAT2/GLT-1, such as ceftriaxone and LDN/OSU-0212320, have been described to have significant protective effects in animal models of amyotrophic lateral sclerosis and epilepsy. In addition, pharmacological activators of the activity of EAAT2/GLT-1 have been explored for decades and are currently emerging as promising tools for neuroprotection, having potential advantages over expression activators. This review describes the current status of the search for EAAT2/GLT-1 activators and addresses challenges and limitations that this approach might encounter.
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Details
- Title
- Current approaches to enhance glutamate transporter function and expression
- Creators
- Andreia C. K. Fontana - Drexel University
- Publication Details
- Journal of neurochemistry, v 134(6), pp 982-1007
- Publisher
- Wiley
- Number of pages
- 26
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000362827600002
- Scopus ID
- 2-s2.0-84941804861
- Other Identifier
- 991020100203204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences