Journal article
Current challenges in the development of new treatments for lupus
Annals of the rheumatic diseases, v 78(6), pp 729-735
01 Jun 2019
PMID: 30636212
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a considerable impact on patients' quality of life. Despite the plethora of clinical trials for SLE since the turn of the millennium, only one new treatment has been approved for the condition, and the overall pace of successful drug development remains slow. Nevertheless, the myriad of clinical studies has yielded insights that have informed and refined our understanding of eligibility criteria, outcome measures and trial design in SLE. In this review, we highlight the achievements of clinical trials as well as the major pitfalls that have been identified in drug development for SLE and, in doing so, identify areas where collaboration and consensus will be important to facilitate progress.
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Details
- Title
- Current challenges in the development of new treatments for lupus
- Creators
- Maria Dall'Era - University of California, San FranciscoIan N Bruce - Manchester Academic Health Science CentreCaroline Gordon - University of BirminghamSusan Manzi - Allegheny Health NetworkJanis McCaffrey - Community Based Research CentrePeter E Lipsky - Ampel BioSolutions (United States)
- Publication Details
- Annals of the rheumatic diseases, v 78(6), pp 729-735
- Publisher
- British Medical Journal (BMJ)
- Grant note
- MR/M01665X/1 / Medical Research Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000471072800020
- Scopus ID
- 2-s2.0-85059879870
- Other Identifier
- 991021934007904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology