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Journal article
Current concepts in treating mild cognitive impairment in Parkinson's disease
Neuropharmacology, v 203, 108880
01 Feb 2022
PMID: 34774549
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Impairment in various aspects of cognition is recognized as an important non-motor symptom of Parkinson's disease (PD). Mild cognitive impairment in PD (PD-MCI) is common in non-demented PD patients and is often associated with severity of motor symptoms, disease duration and increasing age. Further, PD-MCI can have a significant negative effect on performance of daily life activities and may be a harbinger of development of PD dementia. Thus, there is significant interest in developing therapeutic strategies to ameliorate cognitive deficits in PD and improve cognitive functioning of PD patients. However, due to significant questions that remain regarding the pathophysiology of cognitive dysfunction in PD, remediation of cognitive dysfunction in PD has proven difficult. In this paper, we will focus on PD-MCI and will review some of the current therapeutic approaches being taken to try to improve cognitive functioning in patients with PD-MCI.
This article is part of the Special Issue on ‘New therapeutic approaches to Parkinson’s disease'.
•Cognitive dysfunction is an important non-motor symptom of Parkinson's disease.•PD-MCI is common but has proven difficult to treat.•Current therapeutic approaches to improve cognition in PD are discussed.
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Details
- Title
- Current concepts in treating mild cognitive impairment in Parkinson's disease
- Creators
- Jay S. Schneider - Thomas Jefferson UniversitySandhya Kortagere - Drexel University
- Publication Details
- Neuropharmacology, v 203, 108880
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000721678200002
- Scopus ID
- 2-s2.0-85119153210
- Other Identifier
- 991019167897304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy