Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Current employment status, occupational category, occupational hazard exposure and job stress in relation to telomere length: the Multiethnic Study of Atherosclerosis (MESA)
Occupational and environmental medicine (London, England), v 70(8), pp 552-560
Aug 2013
PMID: 23686115
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Telomere length has been proposed as a biomarker of cell senescence, which is associated with a wide array of adverse health outcomes. While work is a major determinant of health, few studies have investigated the association of telomere length with various dimensions of occupation. Accelerated cellular aging could be a common pathway linking occupational exposure to several health outcomes. Methods Leukocyte telomere length was assessed using quantitative PCR in a community-based sample of 981 individuals (age: 45–84 years). Questionnaires were used to collect information on current employment status, current or main occupation before retirement and job strain. The Occupational Resource Network (O*NET) database was linked to the questionnaire data to create five exposure measures: physical activity on the job, physical hazard exposure, interpersonal stressors, job control and job demands. Linear regression was used to estimate associations of occupational characteristics with telomere lengths after adjustment for age, sex, race, socioeconomic position and several behavioural risk factors. Results There were no mean differences in telomere lengths across current employment status, occupational category, job strain categories or levels of most O*NET exposure measures. There was also no evidence that being in lower status occupational categories or being exposed to higher levels of adverse physical or psychosocial exposures accelerated the association between age and telomere shortening. Conclusions Cellular aging as reflected by shorter telomeres does not appear to be an important pathway linking occupation to various health outcomes.
Metrics
Details
- Title
- Current employment status, occupational category, occupational hazard exposure and job stress in relation to telomere length: the Multiethnic Study of Atherosclerosis (MESA)
- Creators
- Kaori Fujishiro - National Institute for Occupational Safety and HealthAna V Diez-Roux - University of MichiganPaul A Landsbergis - SUNY Downstate Health Sciences UniversityNancy Swords Jenny - University of VermontTeresa Seeman - University of California, Los Angeles
- Publication Details
- Occupational and environmental medicine (London, England), v 70(8), pp 552-560
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000322114400006
- Scopus ID
- 2-s2.0-84880698632
- Other Identifier
- 991020112081404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health